Resident Evil: Retribution continues the story of Alice as she fights alongside a resistance movement in the continuing battle against the Umbrella Corporation and the undead. The Umbrella Corporation's deadly T-virus continues to ravage the Earth, transforming the global population into legions of the flesh eating Undead. The human race's last and only hope, Alice, awakens in the heart of Umbrella's most clandestine operations facility and unveils more of her mysterious past as she delves further into the complex.

The action/horror film is written and directed by Paul W.S. Anderson. It stars Milla Jovovich as Alice, Michelle Rodriguez as Rain Ocampo, Sienna Guillory as Jill Valentine, Kevin Durand as Barry Burton, Oded Fehr as Carlos Oliveira, Bingbing Li as Ada Wong, Shawn Roberts as Albert Wesker, and Johann Urb as Leon Kennedy.