Take a look at the first trailer for Mass Effect: Andromeda
We have been waiting since 2012 for this.
BioWare has finally given us our first look at the latest installment in the Mass Effect series and it has totally been worth the wait. There was a bit of a hullabaloo over Mass Effect 3's ending, but that shouldn't be an issue in the latest game in the franchise -- BioWare has promised to make theis game "right" instead of "fast."
As you can see, Commander Shepard won't be returning in this game and you wont be playing as soldier in the same universe that Shep exists in, but seperated by time and lots of space. In fact, there won't be many familiar faces in the game.
Remember, this isn't Mass Effect 4 -- this is the next game in the series, Mass Effect: Andromeda.